Consider using a humidified CPAP. It took me 3 months to figure out the right pressure and right mask, but these 12 years of CPAP use have been extremely well-worth it and it has enhanced the quality of my sleep specifically, and life in general. If you can tolerate it, go for it.
There is nothing like a steady stream of moisturized air all night long. This replaces what the empty nose syndrome (ENS) nose cannot do - air condition the inspired air - and it makes a huge difference for me. The best part is there's no real risk to using a CPAP, as it is water and air - that is it! No need to worry about side effects from pharmaceutical medicines.